Endoplasmin



Endoplasmin is a heat shock 90Kda protein. It is also called 94Kda glucose-regulated protein or GRP94. It is a constituent of the endoplasmic reticulum. It is Ca2+ binding. The images at the left and at the right correspond to one representative Endoplasmin, i.e. the crystal structure of dog Endoplasmin (GRP94, 2o1v). Adenosine-5'-diphosphate (ADP) is shown as a space filling object.

3D Structures of Endoplasmin
2o1u – dGRP94+AMPPNP – dog

2o1v - dGRP94+ADP

2o1t – dGRP94 middle and C-terminal domains

2o1w - dGRP94 middle and N-terminal domains

2hg1, 2hch, 2gqp - dGRP94 N-terminal domain+carboxyamido adenosine

2h8m - dGRP94 N-terminal domain+2-iodo-NECA

2gfd - dGRP94 N-terminal domain+radamine

2fyp - dGRP94 N-terminal domain+radester amine

2exl - dGRP94 N-terminal domain+geldanamycin

2esa - dGRP94 N-terminal domain (mutant)+geldanamycin

1u0z, 1qy8 - dGRP94 N-terminal domain+radicicol

1ysz, 1u2o, 1qy5 - dGRP94 N-terminal domain+NECA

1yt0, 1tc6 - dGRP94 N-terminal domain+ADP

1tbw - dGRP94 N-terminal domain+AMP

1tc0 - dGRP94 N-terminal domain+ATP

1u0y - dGRP94 N-terminal domain+n-propyl carboxyimido adenosine

1yt1, 1yt2 - dGRP94 N-terminal domain (mutant)

1qye - dGRP94 N-terminal domain+2-chlorodideoxyadenosine